Dense Irregular Connective Tissue

Dense Irregular Connective Tissue

Dense irregular connective tissue (DICT) consists of a somewhat dense arrangement of thick collagen type I fibers embedded, along with a smattering of fibroblasts, in an amorphous ground substance. Characteristically, dense irregular connective tissue differs from loose connective tissue in three basic ways:

  • The most abundant part of dense irregular connective tissue are the collagen type I fibers, not the amorphous ground substance.
  • The extracellular fibers of DCT are nearly entirely collagen type I fibers.
  • The cells of DCT are less abundant and are virtually all fibroblasts; few other cells, if any, are present.

Dense irregular connective tissue has an irregular, somewhat disorderly, dense weave of thick collagen type I fibers, with bundles of fibers oriented in all directions. With its high tensile strength, dense irregular connective tissue effectively binds various tissues together to form organs and passively translates mechanical forces in all directions without tearing. Unlike loose connective tissue, it is NOT a designed to be a theatre of inflammation.

Dense irregular connective tissue is found in several locations: the dermis of the skin, the walls of large tubular organs, such as the alimentary canal, in glandular tissue, and in organ capsules.



Copyright © 2009 Stephen Gallik, Ph. D.